Informatics Publishing Limited

G. P. Dubey , A. Agrawal , S. P. Dixit

Abstract

Objective: To study the beneficial role of Seabuckthorn (Hippophae rhamnoides) in the maintenance of cardiovascular homeostasis following cold stress. Materials and Methods: The effect of the alcoholic extract of Seabuckthorn in the daily oral dose of 500 mg was studied on various electrophysiological and neurochemical parameters following cold stress among the positive cold stress responders (human subjects) continuously for 3 months. Results: The average differences in cardiovascular responses like systolic and diastolic blood pressure, and pulse rate that were found to be raised following cold pressor test, minimized following three months oral administration of Seabuckthorn. Further, the psychophysiological parameters like occipito frontalis EMG and galvanic skin resistance also regulated under drug treatment. The serotonin and plasma cortisol levels were also modified following oral administration of Seabuckthorn. Conclusion: Seabuckthorn exhibited beneficial effects to reduce the cardiovascular reactivity following cold stress and thus it enhances the stress tolerance capacity as well as better adaptation towards stress.

Keywords

Homeostasis, Seabuckthorn, Cold Pressor Test, Cardiovascular Reactivity, Serotonin

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A. Agrawal , K. Mittal , A. R. Thakkar

Abstract

A simple, accurate, economical, fast and reliable method for the determination of lercanidipine (LR) is highly desirable to support formulation screening and quality control. The method was developed for determination of LR in pure drug and tablet dosage form. Best results were shown in terms of linearity, accuracy, precision, LOD and LOQ for pure drug as well as for tablets. UV absorbance was measured at 332 nm. Excellent linearity (correlation coefficient (r²) = 0.9970) found in the concentration range of 7.5-60 μg/ml. The LOD and LOQ were 1.0770 and 3.2638 μg/ml respectively and good recoveries were achieved (95.779%).

Keywords

Lercanidipine, Methanol, Zero Order Spectra, First Derivative Zero Crossing Spectrophotometer.

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S. R. Kane ¹, A. Agrawal ², S. N. Jha

Affiliations
1 Indus Synchrotrons Utilization Division, Raja Ramanna Centre for Advanced Technology, Indore- 452013, IN
2 Atomic and Molecular Physics Division, Bhabha Atomic Research Centre, Mumbai-400085, IN

Abstract

A new X-ray absorption fine structure (EXAFS) data acquisition and data analysis program is developed using LabVIEW. It runs under window operating system and offers several unique features. It has a user friendly graphical user environment and is capable of saving data in variety of formats. The availability of online data presentation is particularly useful for data examination during the EXAFS experiments as well as analysing quality of the sample. Transmission and Fluorescence mode are implemented to characterize variety of samples.

Keywords

LabVIEW, EXAFS, Beamline, DAQ.

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K. K. Yadav ¹, N. Chouhan ², R. Thubstan ², S. Norlha ², J. Hariharan ², C. Borwankar ², P. Chandra ², V. K. Dhar ¹, N. Mankuzhyil ², S. Godambe ², M. Sharma ², K. Venugopal ², K. K. Singh ¹, N. Bhatt ², S. Bhattacharyya ¹, K. Chanchalani ², M. P. Das ², B. Ghosal ², S. Godiyal ², M. Khurana ², S. V. Kotwal ², M. K. Koul ², N. Kumar ², C. P. Kushwaha ², K. Nand ², A. Pathania ², S. Sahayanathan ¹, D. Sarkar ², A. Tolamati ², R. Koul ³, R. C. Rannot ⁴, A. K. Tickoo ⁵, V. R. Chitnis ⁶, A. Behere ⁷, S. Padmini ⁷, A. Manna ⁷, S. Joy ⁷, P. M. Nair ⁷, K. P. Jha ⁷, S. Moitra ⁷, S. Neema ⁷, S. Srivastava ⁷, M. Punna ⁷, S. Mohanan ⁷, S. S. Sikder ⁷, A. Jain ⁷, S. Banerjee ⁷, Krati ⁷, J. Deshpande ⁷, V. Sanadhya ⁸, G. Andrew ⁸, M. B. Patil ⁸, V. K. Goyal ⁸, N. Gupta ⁸, H. Balakrishna ⁸, A. Agrawal ⁸, S. P. Srivastava ⁹, K. N. Karn ⁹, P. I. Hadgali ⁹, S. Bhatt ⁹, V. K. Mishra ⁹, P. K. Biswas ⁹, R. K Gupta ⁹, A. Kumar ⁹, S. G. Thul ⁹, R. Kalmady ¹⁰, D. D. Sonvane ¹⁰, V. Kumar ¹⁰, U. K. Gaur ¹⁰, J. Chattopadhyay ¹¹, S. K. Gupta ¹¹, A. R. Kiran ¹¹, Y. Parulekar ¹¹, M. K. Agrawal ¹¹, R. M. Parmar ¹¹, G. R. Reddy ¹², Y. S. Mayya ¹³, C. K. Pithawa ¹⁴

Affiliations
1 Astrophysical Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India; Homi Bhabha National Institute, Mumbai 400 085, India, IN
2 Astrophysical Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
3 Formerly at Astrophysical Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
4 Raja Ramanna Fellow at Astrophysical Sciences Division, Mumbai 400 085, India, IN
5 Deceased, IN
6 Department of High Energy Physics, Tata Institute of Fundamental Research, Mumbai 400 005, India, IN
7 Electronics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
8 Control and Instrumentation Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
9 Center for Design and Manufacture, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
10 Computer Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
11 Reactor Safety Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
12 Formerly at Reactor Safety Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
13 Formerly at Reactor Control Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
14 Formerly at Electronics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN

Abstract

The MACE telescope has recently been commissioned at Hanle, Ladakh, India. It had its first light in April 2021 with a successful detection of very high energy gamma-ray photons from the standard candle Crab Nebula. Equipped with a large light collector of 21 m diameter and situated at an altitude of ~4.3 km amsl, the MACE telescope is expected to explore the mysteries of the non-thermal Universe in the energy range above 20 GeV with very high sensitivity. It can also play an important role in carrying out multi-messenger astronomy in India.

Keywords

Gamma-ray astronomy, high energy radiative processes, non-thermal Universe, telescope.

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